Correlation of the biomarker in saliva with the oral tuberculosis in extrapulmonary tuberculosis patients

Nanda Rachmad Putra Gofur; Aisyah Rachmadani Putri Gofur; Soesilaningtyas; Rizki Nur Rachman Putra Gofur

Correlation of the biomarker in saliva with the oral tuberculosis in extrapulmonary tuberculosis patients

Authors
Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Soesilaningtyas, Rizki Nur Rachman Putra Gofur

Abstract
Introduction: Tuberculosis or TB is one of the infectious diseases caused by bacterium called Mycobacterium tuberculosis. It can damage several organs in the body. There are more cases among men than women, Men with aged ≥ 15 years accounted for 56% of the people who had developed TB in 2019, and women accounted for 32%. The TB infection has close correlation with oral cavity and can be seen through the clinical appearance and often associated with the immune system Individuals infected with TB have different levels of salivary marker proteins. Objective: To analyze the correlation of the biomarker saliva with the oral tuberculosis in extrapulmonary tuberculosis patients. Discussion: Saliva has been reported in other disease, including leukaemia, oral cancer, oral lichen planus and several periodontal diseases. Saliva also can be used as the diagnostic sample in biomarker of TB. IL-2 is an important immunomodulatory cytokine produced by several cell types including activated T cells, dendritic cells, and NK cells and is essential both for the immune response to many infectious diseases and for the maintenance of tolerance. IL-6 has previously been shown to be produced at higher levels in TB patients. Conclusion: Several biomarkers in saliva has been used as a tool to do the early detection of oral tuberculosis due to the easy sampling method and the high level of host markers in saliva showed that these markers may be more reliably as a sample in early detection of oral tuberculosis.

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