Melatonin has immunomodulatory and cancer prevention agent exercises, invigorates the expansion of collagen and bony tissue, and goes about as a defender against cell degeneration related with maturing and poison introduction. Emerging out of its cancer prevention agent activities, melatonin ensures against incendiary procedures and cell harm brought about by the poisonous derivates of oxygen. In this review we will show how melatonin is helpful in oral health.