Ozone has been used successfully for the management of various diseases for more than a decade. It has unique properties that includes immunmodulation, analgesic, detoxicating, antimicrobial, bioenergetic and biosynthetic actions. Application of ozone is painless, non-invasive in nature, and relative absence of discomfort and side effects increase the patient’s acceptance and compliance thus making it an ideal treatment choice specially for pediatric and apprehensive patients. Present review aims to highlight various application of ozone therapy in dentistry and its possible clinical applications in future.