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VOL. 6, ISSUE 1 (2024)
Review of the effectiveness of andaliman fruit extract (Zanthoxylum Piperitum) in healing wounds after tooth extraction in wistar rats
Authors
Yuan Zixiang
Abstract
Andaliman contains phenols, monoterpenes, sesquiterpenes, nones, and
essential oils belonging to the group of terpenoid compounds. Based on its
chemical composition and physiological activity, the use of andaliman can be
increased in various fields, including spices, preservatives, drugs and
supplements, and vegetable pesticides. This study aimed to evaluate the
effectiveness of andaliman fruit extract (Zanthoxylum piperitum) at
concentrations of 50% and 100% in the wound healing process after tooth
extraction in rats. Experimental research in this laboratory used a randomized
design complete with a post-test-only control group design pattern. This study
used 32 male white rats of the Wistar strain who were physically healthy, aged
2-3 months, and weighed between 200-250 grams. These rats were divided into two
groups where 16 received treatment with 50% Andaliman fruit extract
(Zanthoxylum Piperitum) and 16 others received treatment with 100% Andaliman
fruit extract (Zanthoxylum Piperitum). This group division aims to compare the
acceleration of wound healing after tooth extraction. The research method used
was purely experimental, and statistical analysis was performed with a
non-parametric Chi-Square Test after the test showed that (p<0.05),
indicating a significant difference between groups. The results showed that
there was a significant relationship between the number of fibroblast tissues
per field of view in Wistar rats after tooth extraction with the administration
of Andaliman Fruit Extract (Zanthoxylum piperitum) concentration of 50% and
Andaliman Fruit Extract (Zanthoxylum piperitum) concentration of 100%, with a
value of p = 0.003 (p < 0.05). Based on the results and discussion of the
study, it can be concluded that Andaliman Fruit Extract (Zanthoxylum piperitum)
at concentrations of 50% and 100% is effective in accelerating the healing time
of wounds after tooth extraction in Wistar rats.
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Pages:13-16
How to cite this article:
Yuan Zixiang "Review of the effectiveness of andaliman fruit extract (Zanthoxylum Piperitum) in healing wounds after tooth extraction in wistar rats". International Journal of Dental Sciences, Vol 6, Issue 1, 2024, Pages 13-16
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