The purpose of our systematic review and meta-analysis was to investigate long term side effects of cone beam computed tomography investigations used regularly now a days in orthodontic treatment modalities. 6 studies were included in the meta analysis finally excluding articles which didn’t meet our inclusion criteria. The results concluded that the cone beam computed tomography imaging highlighted a critical concern regarding the increasing use in paediatric orthodontics. Younger age groups (5-10 years) exhibit significantly higher percentages of risk of cancer compared to older age groups.