Background: Coe-Pak is a widely used periodontal dressing applied post-surgically to protect the wound site, facilitate healing, and reduce postoperative discomfort. However, conventional Coe-Pak formulations have been associated with several limitations, including increased plaque accumulation, excessive granulation tissue formation, and cytotoxic effects on gingival fibroblasts during the early healing phase. Additional concerns include suboptimal setting time, poor aesthetic appearance, and heightened tissue reactions compared to alternatives like PerioPutty.

Objective: To enhance the healing efficacy and patient comfort associated with periodontal dressings by developing a novel Coe-Pak formulation infused with betel leaf extract.

Innovation: The proposed betel leaf extract-infused Coe-Pak leverages the natural antibacterial, anti-inflammatory, and wound-healing properties of betel leaf to address the drawbacks of conventional dressings. This targeted approach aims to reduce cytotoxicity, minimize plaque retention, and improve tissue response, thereby promoting faster and more comfortable postoperative recovery.