Background: Early recognition and correction of developing malocclusions during the mixed dentition period play a vital role in achieving a stable and harmonious occlusion. The 2×4 fixed appliance is a simple yet effective interceptive orthodontic tool that allows precise control of anterior tooth movement, alignment, and incisor inclination.

Case Presentation: This case report describes the management of a 10-year-old child presenting with malalignment of the left maxillary central incisor in the mixed dentition phase. Diagnosis revealed a retained deciduous tooth. Interceptive orthodontic therapy was initiated using a 2×4 fixed appliance comprising bands on the first permanent molars and bonded brackets on the maxillary incisors. Sequential alignment was achieved with light nickel–titanium archwires. The appliance successfully corrected the incisor malalignment within 4 months, resulting in improved aesthetics and alignment.