Introduction: Ceramic veneers are a conservative and highly aesthetic restorative option widely used in anterior dentistry. Despite their clinical popularity, long-term success depends on the mechanical behavior of the restorative material under functional and parafunctional loads.

Objective: To evaluate stress distribution and fatigue resistance of dental veneers fabricated from monolithic zirconia, lithium disilicate, and feldspathic ceramic using three-dimensional finite element analysis.

Materials and Methods: A maxillary central incisor prepared for a veneer was digitally modeled and restored with veneers of identical geometry fabricated from the three materials. Static oblique loading and cyclic fatigue loading were applied to simulate clinical conditions. Von Mises stress, total displacement, and fatigue life were assessed.

Results: Monolithic zirconia demonstrated the lowest stress concentration, minimal displacement, and the longest fatigue life. Lithium disilicate exhibited intermediate performance, while feldspathic ceramic showed the highest stress values and the lowest fatigue resistance.

Conclusion: Material selection significantly influences the biomechanical performance of veneers. Monolithic zirconia showed superior resistance under static and cyclic loads, suggesting its indication for patients with high functional demand.