Background: Dual antiplatelet therapy (DAPT) using clopidogrel and aspirin is standard for preventing thrombotic events, particularly in patients with acute coronary syndromes or undergoing percutaneous coronary intervention. Dental extractions in patients on DAPT pose bleeding concerns.

Aim: To assess the safety and efficacy of a protocol for dental extractions in patients on DAPT.

Materials and Methods: Forty patients on DAPT underwent dental extractions at Pacific Dental College and Hospital, Udaipur (2021–2023). Group I (20 patients) continued DAPT, while Group II (20 patients) ceased DAPT three days before surgery. Hemostasis was managed using dry gauze (45 min), gauze soaked in tranexamic acid (TXA), gel foam, or 1% feracrylum. Patients were provided sutures, post-op instructions, and emergency contact. Follow-ups were done at 24 hours (phone) and in-person on days 3, 7, and 10.

Results: No postoperative bleeding occurred in patients who continued DAPT. Minor immediate bleeding was effectively managed with gel foam and TXA, with no cases requiring transfusion. Basic hemostatic measures and suturing were sufficient.